Werner Wolf is a newspaper science editor who hires Scooby, Shaggy, and Scrappy as typists at a science building. While the trio performed their duties, Wolf was busy with an experiment on stone age studies, using his latest invention in hopes of completing his work. When he steps between the electrodes of the device, Wolf emerges as a villainous wolfman. Wolf's heel persona plagues Scooby when he turns in his work, but when the panicked canine runs to Shaggy regarding his discovery, Wolf appears in his normal human form and politely asks for coffee.
While the trio prepares coffee, Wolf turned heel again and transformed into his werewolf form, and this time, all three see Wolf in his lycanthropic form. The entire episode has the villainous werewolf scientist chasing the trio, snarling and growling during his pursuit. The climax has Scrappy becoming a wolf creature during the pursuit, and in his form, he successfully defeats the evil wolfman and sent him toward the invention, which turned him fully back to normal.